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目的分析石家庄市2009年-2012年手足口病的病原学特征,为手足口病防控提供依据。方法在全市24个县(市/区)采集的手足口病(HFMD)患者临床标本,采用RT-PCR或Real time RT-PCR的方法对通用肠道病毒(EV)、肠道病毒71型(EV71)和柯萨奇病毒A16型(CA16)特异核酸进行检测。结果 3360份临床标本中,检出肠道病毒阳性样品2699份,EV71与CA16合计2274份,检出率67.68%;2009年与2012年主要流行病原为CA16,2010年与2011年为EV71;同一年份,24个县(市/区)的病原构成不同;不同年份,同一县(市/区)病原构成不同;重症病例和死亡病例感染病原以EV71为主。结论石家庄市HFMD的病原构成和流行规律复杂,防控难度较大。需持续加强对不同县(市/区)HFMD的流行病学与病原学监测,采取有针对性的防控措施,有效控制HFMD的流行。
Objective To analyze the etiological characteristics of hand-foot-mouth disease in Shijiazhuang from 2009 to 2012, and provide evidence for the prevention and control of hand-foot-mouth disease. Methods The clinical specimens of hand, foot and mouth disease (HFMD) patients collected in 24 counties (cities / districts) of the city were analyzed by RT-PCR or Real time RT-PCR on the common enterovirus (EV), enterovirus 71 EV71) and Coxsackievirus A16 (CA16) specific nucleic acids. Results Among the 3360 clinical samples, 2699 positive samples of enterovirus were detected, and 2274 were EV71 and CA16, with a detection rate of 67.68%. The major epidemic pathogens in 2009 and 2012 were CA16, and the EV71 was in 2010 and 2011. The same In the year, the pathogenic constitutions of 24 counties (cities / districts) were different; in different years, the same county (city / district) had different pathogens; EV71 was the most common infectious disease in severe cases and deaths. Conclusion The pathogen composition and epidemic pattern of HFMD in Shijiazhuang are complex and difficult to control. It is necessary to continuously strengthen the epidemiological and etiological monitoring of HFMD in different counties (cities / districts) and take targeted prevention and control measures to effectively control the epidemic of HFMD.