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小气道和肺泡的进展性炎症及纤维性改变是多种间质性肺疾病(ILD)发病机制中共同的最终病理变化.单核细胞(MC)和巨噬细胞(Mφ)对肺纤维化过程中诸多重要因素的协调起关键作用.这些细胞产生多种细胞因子,促进纤维母细胞(Fb)增生,合成胶原和其他基质蛋白。血小板源性生长因子(PDGF)和转化生长因子(TGFβ)是其中特别重要的生长因子.为了确定ILD 患者肺泡巨噬细胞(A-Mφ)是否参与生长因子产生,作者通过支气管肺泡灌洗获得46例ILD 患者和14例对照者(包括11例健康人和3例COPD 患者)的A-Mφ,采用“Slot blots”和Northern analysis 测定不同条件下A-Mφ的
Progressive inflammatory and fibrotic changes in small airways and alveoli are common pathological changes in the pathogenesis of a variety of interstitial lung diseases (ILDs). The effects of monocytes (MCs) and macrophages (Mφs) on pulmonary fibrosis The coordination of many important factors plays a key role in the production of many cytokines, promoting the proliferation of fibroblasts (Fb), the synthesis of collagen and other matrix proteins. Platelet-derived growth factor (PDGF) and transforming growth factor (TGFβ) are the most important growth factors among them.In order to determine if alveolar macrophages (A-Mφ) in ILD patients are involved in the production of growth factors, the authors obtained bronchoalveolar lavage A-Mφ in patients with ILD and in 14 controls (including 11 healthy controls and 3 patients with COPD) were measured using “Slot blots” and Northern analysis for A-Mφ