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目的探讨儿童新型抗癫痫药物口服过量的不良反应特点,促进安全用药。方法以2例分别口服奥卡西平和拉莫三嗪过量的儿童患者为例,结合文献报道阐述其中毒后的主要临床表现、实验室指标、治疗过程及预后。结果与结论本研究中2例分别口服奥卡西平和拉莫三嗪过量中毒病例的临床表现主要以呕吐和腹痛等胃肠道症状为主,嗜睡和呼吸抑制相对于传统抗癫痫药(如卡马西平、苯巴比妥等)较轻。及时采取对症治疗后2例患者预后均较为良好。临床需注意做好鉴别诊断和血药浓度监测。
Objective To investigate the characteristics of adverse reactions of oral antiepileptic drugs orally in children and to promote safe medication. Methods Two cases of orally given oxcarbazepine and lamotrigine overdose in children, respectively, as an example, combined with the literature reported the main clinical manifestations after poisoning, laboratory parameters, treatment and prognosis. RESULTS AND CONCLUSION: The clinical manifestations of two cases of oral oxcarbazepine and lamotrigine overdose poisoning were mainly gastrointestinal symptoms such as vomiting and abdominal pain. Sleepiness and respiratory depression were significantly lower than those of traditional antiepileptic drugs Macassin, phenobarbital, etc.) lighter. Two cases of symptomatic treatment after timely treatment of patients with better prognosis. Clinical need to pay attention to differential diagnosis and blood concentration monitoring.