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目的:了解本地区女性HPV的感染情况及型别分布,以助于HPV疫苗的研制和应用。方法:采用快速分子导流杂交分型技术对4314例女性HPV的感染情况及型别分布进行分析。结果:HPV感染阳性率为41.68%(1798/4314)。10组年龄组中筛查人群以31岁～50岁的妇女为主,占72.02%(3107/4314);HPV阳性率以21岁～25岁(56.86%)及≥60岁(64.39%)的年龄组较高。各年龄组均以单重感染为主,其次为双重感染。在单重感染下,高危亚型均以HPV16、52、58为主,其次为HPV18、33;低危亚型以HPV6、11为主;常见亚型以HPV53、cp8304(81)为主。结论:温州地区女性HPV感染以单重感染为主,高危亚型优势型别为HPV16、52、58,低危亚型优势型别为HPV6、11,常见亚型优势型别为HPV53、cp8304(81)。
Objective: To understand the HPV infection in this area and the type distribution of HPV in order to help the development and application of HPV vaccine. Methods: The infection status and type distribution of 4314 women with HPV were analyzed by rapid molecular flow-based hybridization. Results: The positive rate of HPV infection was 41.68% (1798/4314). Among the 10 age groups, the screening population was mainly women aged 31 to 50 years, accounting for 72.02% (3107/4314). The positive rates of HPV were 21 ~ 25 (56.86%) and ≥60 (64.39%) The age group is higher. In all age groups were single infection, followed by double infection. In the single infection, high-risk subtypes were mainly HPV16,52,58, followed by HPV18,33; low-risk subtype HPV6,11-based; common subtype HPV53, cp8304 (81) based. Conclusion: The prevalence of HPV infection in women in Wenzhou area is mainly single infection, the high risk subtypes are HPV16, 52 and 58, the low risk subtypes are HPV6 and 11, and the common subtypes are HPV53 and cp8304 81).