论文部分内容阅读
目的研究抗痨药引起肝损害的特点及防治方法。方法对2002年1月至2009年12月在中平能化医疗集团总医院感染科住院的抗痨药引起肝损害患者72例进行回顾性分析。结果抗痨药引起肝损害多发生在12周内,少数无临床症状,轻者继续抗痨加用保肝治疗,重者停止抗痨加用保肝治疗,71例肝功均恢复正常。结论对抗痨药引起肝损害的高危患者制订抗痨方案要选择肝毒性较小的药物,加强肝功监测,并视肝损情况予保肝治疗或停药。
Objective To study the characteristics of anti-drug induced liver damage and prevention methods. Methods A retrospective analysis was performed on 72 patients with liver damage caused by antituberculosis drugs admitted to the Infectious Diseases Section of the General Hospital of Zhongping Nenghua Medical Group from January 2002 to December 2009. Results Anti-drug induced liver damage occurred in more than 12 weeks, a small number of no clinical symptoms, the light continued to anti-痨 plus liver treatment, severe anti-痨 plus liver treatment, 71 cases of liver function returned to normal. Conclusions To develop anti-tuberculosis drugs for patients at high risk of liver damage caused by spironolactone should select drugs with less hepatotoxicity, strengthen the monitoring of liver function and treat or stop the treatment depending on the liver damage.