论文部分内容阅读
选择双硫代苯乙酸-1-苯基乙酯(PEPD)为RAFT试剂、以过氧化二异丙苯(DCP)为引发剂、在130℃下,茴香醚中实现了1,2:3,4-di-O-异亚丙基-6-O-(2’-甲醛-4’-苯乙烯基)-D-半乳糖(IVDG)和5,6-苯基-2-亚甲基-1,3-二氧七环(BMDO)的“活性”/可控RAFT自由基共聚合.Mn基本上随单体转化率线性增加,整个反应过程保持较窄的分子量分布(Mw/Mn～1.4),表明以上自由基共聚合体系呈现可控特征.1H-NMR的分析进一步证实了聚合物链的末端精细结构.此外,该共聚物经KOH处理后,聚合物的分子量很明显地向低分子量部分移动,且分布变宽,表明IVDG-BMDO共聚物是可以水降解的.经88%甲酸处理后,脱去保护基团,形成两亲性共聚物,该两亲性共聚物不需要外加乳化剂,在水中能够自组装形成含有大量半乳糖的、可生物降解的、醛基功能化的纳米微球.
1-Phenylethyl dithiobenzeneacetate (PEPD) was selected as the RAFT reagent and dicumylperoxide (DCP) was used as the initiator to make 1,2: 3 anisole at 130 ℃. 4-di-O-isopropylidene-6-O- (2’-carboxaldehyde-4’- styryl) -D- galactose (IVDG) and 5,6-phenyl- 1,3-dioxane (BMDO) “active ” / controlled RAFT free radical copolymerization.Mn basically increases linearly with the monomer conversion, the entire reaction process to maintain a narrow molecular weight distribution (Mw / Mn ~ 1.4), indicating that the above free radical copolymerization system showed controlled characteristics.1H-NMR analysis further confirmed the terminal fine structure of the polymer chain.In addition, the copolymer after KOH treatment, the molecular weight of the polymer is very clear The low molecular weight portion migrated and the distribution became wider, indicating that the IVDG-BMDO copolymer was water-degradable.After treatment with 88% formic acid, the protective group was removed to form an amphiphilic copolymer that did not require In addition, the emulsifier can self-assemble in water to form biodegradable aldehyde functionalized nanospheres containing a large amount of galactose.