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(+)-Cyanidanol是一种新合成的Flavonoid,在实验动物中,可降低乙醇等化合物的肝毒性。它有强大的清除自由基团的作用。已报告在急性病毒性肝炎患者中能降低血清胆红素。本文报道在瑞士、西德、丹麦等多个研究中心协作下,用随机抽样和双盲法观察此药对急性病毒性肝炎的疗效。100例急性病毒性肝炎分为两组。治疗组51例用(+)-Cyanidanol-3,每天2克,共4周,对照组49例用安慰剂。在治疗后第10与第24天之间,治疗组血清胆红素浓度下降50%,比对照组为快,统计学上有显著差异。其中75例HBsAg阳性患者,治疗组在改善腹部不适、厌食、恶心和皮肤搔痒等症状方面,与对照组相比,在统计学上亦有显著差异。治疗
(+) - Cyanidanol is a newly synthesized Flavonoid that reduces the hepatotoxicity of compounds such as ethanol in experimental animals. It has a powerful free radical scavenging effect. Serum bilirubin has been reported in patients with acute viral hepatitis. This article reports the efficacy of this drug in acute viral hepatitis with random sampling and double-blind method in collaboration with several research centers in Switzerland, West Germany and Denmark. 100 cases of acute viral hepatitis are divided into two groups. Fifty-one patients in the treatment group were treated with (+) - Cyanidanol-3, 2 grams daily for 4 weeks, and 49 patients in the control group were treated with placebo. Between the 10th and 24th days after treatment, the serum bilirubin concentration in the treatment group decreased by 50%, which was faster than that in the control group, and there was a statistically significant difference. Of the 75 HBsAg-positive patients, the treatment group had statistically significant differences in terms of improvement of symptoms such as abdominal discomfort, anorexia, nausea and skin itch compared with the control group. treatment