普瑞博思治疗功能性消化不良的临床研究

• 作 者: 陈贤鸿 王炳芳 陈锡美
• 出 处: 上海铁道大学学报(医学辑)
• 发表日期: 1999年09期
• 关键词: 消化不良 功能性 胃排空 普瑞博思 药物治疗

目的　探讨功能性消化不良与胃排空的关系及普瑞博思的治疗作用。方法　观察普瑞博思对 ６８ 例功能性消化不良患者的治疗作用。胃排空时间测定采用放射学技术检测法。结果　普瑞博思治疗疗程结束时，显效率５６５％ ，有效率 ３０４％ ，总有效率 ８６９％ 。液体胃排空时间治疗前后分别为（４０１±９６）ｍ ｉｎ 和（３８７±８９）ｍ ｉｎ，差异无显著性（ Ｐ ＞ ００５）；固体胃排空时间治疗前后分别为（１２０３±２０１０）ｍ ｉｎ 和（９０５±１８０８）ｍ ｉｎ，差异有显著性（ Ｐ＜ ００１）。结论　普瑞博思可明显加快胃排空，对功能性消化不良有显著的治疗作用。

Objective To investigate the relationship between functional dyspepsia and gastric emptying and the therapeutic effect of Puri Booz. Methods The therapeutic effect of Puri Bose on 68 patients with functional dyspepsia was observed. Gastric emptying time determination using radiological techniques. Results Puri Bose treatment at the end of treatment, markedly effective 56  5%, the effective rate of 30  4%, the total effective rate of 86  9%. Liquid gastric emptying time before and after treatment were (401 ± 96) m in and (387 ± 89) mins, the difference was not significant (P> 005); solid gastric emptying time Before and after treatment were (1203 ± 2010) m in and (905 ± 1808) m in, the difference was significant (P <001). Conclusion Pregabalin significantly accelerates gastric emptying and has significant therapeutic effect on functional dyspepsia.