Arrhythmogenic properties of dismantling cadherin-mediated adhesion in murine hearts

• 作 者: Hongjun Zhu Hegui Wang Xiwen Z
• 机 构: DepartmentofCardiology
• 出 处: 生物医学研究杂志：英文版
• 发表日期: 2010年4期
• 关键词: 心律失常 钙粘蛋白 粘附性 小鼠 介导 心脏 拆除 间隙连接蛋白43 adherence junction N-cadherin gap junction
• 基金项目: This work was supported by a grant from Health Department of Jiangsu Province （No. RC2007041） We gratefully acknowledge helpful support Professors Jinan Zhang and Di Yang, as well as University of Sci

目的将评估在鼠科的心由 recombinant 老鼠 aminopeptidase N (rmAPN ) 拆除调停 cadherin 的粘附的 arrhythmogenic 效果。方法 rmAPN 象在成年老鼠被灌输一样与有教养的新生的老鼠 cardiomyocytes 被孵化。房间房间连接是 immunolabelled 并且由激光观察了共焦的显微镜学。N-cadherin (N 恶棍) 的 N 终端的混乱被西方的污点和量的 immunofluorescence 检测。可诱导的室的 tachyarrhy