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目的:总结国内外在乳腺癌中关于PTEN的研究进展,探索其对于乳腺癌治疗的指导作用。方法:利用PubMed数据库检索系统,以“乳腺癌、PTEN、AKT”为关键词,检索近5年的相关文献,共检索到英文文献104篇。纳入标准:1)PTEN来源和分子结构特征;2)PTEN发挥功能的几种途径,特别是PI3K/AKT途径;3)PTEN与乳腺癌治疗的关系。根据纳入标准,最后精选了43篇文章分析。结果:SHIP2、PIK3CA和BRCA1对PTEN的抑癌作用起负性作用,而BMP2、E-钙黏蛋白和p27kip1能促进PTEN的抑癌作用。PTEN表达决定乳腺癌细胞对于化疗药物doxo-rubicin、tamoxifen、ZD1839和trastuzumab的敏感性,却降低了对rapamycin的反应性。结论:虽然已经知道抑癌基因PTEN与乳腺癌密切相关,但其具体机制仍不清楚,需要进一步研究。
OBJECTIVE: To summarize the research progress of PTEN in breast cancer at home and abroad, and to explore its guiding role in the treatment of breast cancer. Methods: The PubMed database search system was used to search for “breast cancer, PTEN, AKT” as the key words, and to retrieve nearly 5 years of related articles, of which 104 articles were retrieved. Inclusion criteria: 1) PTEN origin and molecular structural features; 2) several ways PTEN functions, in particular the PI3K / AKT pathway; and 3) the relationship between PTEN and breast cancer treatment. According to inclusion criteria, the final selection of 43 articles analysis. Results: SHIP2, PIK3CA and BRCA1 had a negative effect on the tumor suppressor activity of PTEN, while BMP2, E-cadherin and p27kip1 could promote the tumor suppressor effect of PTEN. PTEN expression determines the sensitivity of breast cancer cells to chemotherapeutic drugs doxo-rubicin, tamoxifen, ZD1839 and trastuzumab, but decreases the responsiveness to rapamycin. Conclusion: Although it is known that the tumor suppressor gene PTEN is closely related to breast cancer, its specific mechanism remains unclear and needs further study.