论文部分内容阅读
目的:研究鼻腔鼻窦鳞状细胞癌组织中血管内皮生长因子(VEGF)表达的临床病理学意义,同时探讨VEGF与微血管密度(MVD)和微淋巴管密度(MLVD)的关系。方法:采用免疫组织化学法,检测41例鼻腔鼻窦鳞状细胞癌中VEGF的表达,同时标记CD34和D2-40,分别检测鼻腔鼻窦鳞状细胞癌组织中MVD和MLVD。结果:41例鼻腔鼻窦鳞状细胞癌中VEGF表达的阳性率为82.9%(34/41),VEGF的表达与患者性别无关(P>0.05),而与肿瘤的侵犯范围、组织学分级和淋巴结转移相关(P<0.05);VEGF表达阳性组的平均MVD高于阴性组(P<0.05),而平均MLVD阳性组和阴性组之间无统计学差异(P>0.05)。结论:VEGF可能通过促进鼻腔鼻窦鳞状细胞癌的血管形成而参与癌细胞的浸润转移,没有参与鼻腔鼻窦鳞状细胞癌微淋巴管的生成。
Objective: To investigate the clinicopathological significance of vascular endothelial growth factor (VEGF) expression in nasal sinus squamous cell carcinoma and to explore the relationship between VEGF and microvascular density (MVD) and micro-lymphatic vessel density (MLVD). Methods: Immunohistochemical method was used to detect the expression of VEGF in 41 cases of nasal sinus squamous cell carcinoma. CD34 and D2-40 were also labeled to detect MVD and MLVD in squamous cell carcinoma of the nasal cavity. Results: The positive rate of VEGF expression in 41 cases of nasal sinus squamous cell carcinoma was 82.9% (34/41). The expression of VEGF was not related to the gender of the patients (P> 0.05), but was related to the extent of tumor invasion, histological grade and lymph node (P <0.05). The mean MVD of VEGF-positive group was higher than that of negative group (P <0.05), while there was no significant difference between MLVD-positive group and negative group (P> 0.05). Conclusion: VEGF may participate in the infiltration and metastasis of cancer cells by promoting angiogenesis of nasal sinus squamous cell carcinoma, and not participate in the formation of lymphatic vessels in nasal sinus squamous cell carcinoma.