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目的分析甲状腺素对尿毒症患者心功能的影响。方法选取尿毒症患者120例,并按数字表法随机分为对照组与试验组,每组60例。两组患者均接受常规治疗,在此基础上试验组患者给予口服小剂量左甲状腺素钠片的治疗方案。对比分析两组患者治疗前后甲状腺功能、血常规、肾功能各项指标及心功能改善情况。结果试验组血清游离甲状腺原氨酸(FT3)、血清游离甲状腺素(FT4)、血白蛋白、血红蛋白水平均明显高于对照组;试验组血清肌酐(SCr)、尿肌酐(Cr)、血尿素氮(BUN)水平均明显优于对照组;试验组射血分数(EF)、收缩时间间期(STI)、短轴缩短率(FS)值明显高于对照组,差异有统计学意义(P<0.05)。结论对于尿毒症患者,在常规治疗基础上加用小剂量左甲状腺素钠片,可有效改善其心功能及肾功能各项指标,效果较好。
Objective To analyze the effect of thyroxine on cardiac function in uremic patients. Methods 120 patients with uremia were selected and randomly divided into control group and experimental group according to the digital table method, with 60 cases in each group. Both groups received routine treatment, on the basis of which patients in the test group were given oral low-dose levothyroxine sodium tablets. Comparative analysis of two groups of patients before and after treatment thyroid function, blood, kidney function indicators and cardiac function improvement. Results Serum levels of free thyroxine (FT3), serum free thyroxine (FT4), serum albumin and hemoglobin in the experimental group were significantly higher than those in the control group. Serum creatinine (SCr), urine creatinine (Cr) (BUN) were significantly higher than those in the control group. The EF, STI and FS of the experimental group were significantly higher than those of the control group (P <0.05). Conclusion For patients with uremia, the addition of low-dose levothyroxine sodium tablets on the basis of routine treatment can effectively improve the indexes of cardiac function and renal function, and the effect is better.