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目的探讨泮托拉唑预防急性脑梗死并发应激性溃疡(SU)的疗效。方法选取2010年7月—2013年6月黄石市中医医院收治的急性脑梗死患者120例,随机分为治疗组与对照组,各60例。治疗组患者予以泮托拉唑治疗,对照组患者予以法莫替丁治疗。观察两组患者SU发生情况、临床症状(上消化道出血、上腹疼痛、嗳气反酸)及不良反应发生情况。结果治疗组患者SU发生率低于对照组,临床症状发生率低于对照组,差异有统计学意义(P<0.05);两组患者均未发生严重不良反应。结论泮托拉唑预防急性脑梗死并发SU的疗效显著,不良反应小,安全性高。
Objective To investigate the efficacy of pantoprazole in preventing acute cerebral infarction complicated by stress ulcer (SU). Methods From July 2010 to June 2013, 120 patients with acute cerebral infarction admitted to Huangshi Chinese Medicine Hospital were randomly divided into treatment group and control group, with 60 cases each. Patients in the treatment group were treated with pantoprazole, while patients in the control group were treated with famotidine. The occurrence of SU, clinical symptoms (upper gastrointestinal bleeding, abdominal pain, belching acid reflux) and adverse reactions were observed in two groups. Results The incidence of SU in the treatment group was lower than that in the control group, and the incidence of clinical symptoms was lower than that in the control group (P <0.05). No serious adverse reactions occurred in both groups. Conclusions Pantoprazole is effective in preventing acute cerebral infarction complicated by SU with small adverse reactions and high safety.