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目的:系统评价国内谷氨酰胺双肽增强的肠外营养对消化道肿瘤患者术后免疫功能的影响。方法:利用计算机检索中国生物医学文献数据库(2001-2009年)、中国期刊全文数据库(2001-2009年)及中文科技期刊全文数据库(2001-2009年),纳入谷氨酰胺肠外营养对于消化道肿瘤患者术后免疫功能影响的随机对照试验(RCT)文献,手工检索其他相关文献。对纳入的研究进行方法学质量评价,并采用RevMan5.0.20软件进行Meta分析。结果:共有6篇随机对照试验文献的研究符合纳入标准。Meta分析结果显示:术后一周,试验组患者各项免疫指标均有所恢复,其中IgG、IgM、IgA、CD4,以及CD4/CD8比值与对照组有非常显著性差异(P<0.01),CD3与对照组差异有显著性(P<0.05)。结论:含谷氨酰胺双肽的肠外营养可以改善和增强消化道肿瘤患者术后机体的免疫功能。
OBJECTIVE: To systematically evaluate the effect of enhanced glutamine dipeptide-enriched parenteral nutrition on postoperative immune function in patients with gastrointestinal cancer. Methods: The databases of China Biomedical Literature (2001-2009), Chinese Journal Full-text Database (2001-2009) and Chinese Science and Technology Periodicals Full-Text Database (2001-2009) were searched by computer, and glutamine parenteral nutrition Cancer patients with postoperative immune function of randomized controlled trials (RCT) literature, manual retrieval of other relevant literature. The included studies were evaluated for methodological quality and Meta-analysis was performed using RevMan 5.0.20 software. Results: A total of 6 randomized controlled trials of the study met the inclusion criteria. The result of Meta analysis showed that all the immune indexes in the experimental group recovered one week after operation, and the ratios of IgG, IgM, IgA, CD4, and CD4 / CD8 in the experimental group were significantly different from those in the control group (P <0.01) There was significant difference with the control group (P <0.05). Conclusion: Glutamine dipeptide-containing parenteral nutrition can improve and enhance the immune function of postoperative patients with gastrointestinal cancer.