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对卵巢功能衰竭患者行供卵治疗时发现,当月经周期为28天,仅在周期第16～19天内膜才能接受胚胎着床。移植胚胎的发育阶段与受者内膜成熟程度必须同步。由于供卵的时机很难精确预计,临床实践提出了下列问题:①短期雌激素(E)准备能否使内膜有正常分泌期改变?②大剂量孕激素(P)能否加速内膜改变为分泌期?③长期 E 过度刺激对内膜分泌相有无影响?本文目的在于探索应用不同方案的外源性激素治疗时内膜成熟的可能性,以求得供卵与受卵同步化。
Ovarian failure in patients with ovulation treatment found that when the menstrual cycle is 28 days, only in the cycle of 16 to 19 days in order to accept embryo implantation. The developmental stage of the transferred embryo must be synchronized with the endometrial maturity of the recipient. Because the timing of ovulation is difficult to predict accurately, clinical practice has raised the following questions: (1) Can short-term estrogen (E) preparations change the normal secretory phase of the intima; (2) Can the high-dose progestin (P) For the secretion of? ③ long-term E over-stimulation of endometrial secretion has no effect? The purpose of this paper is to explore the application of different options of exogenous hormone therapy in the possibility of endometrial maturation, in order to obtain ovulation and ovulation synchronization.