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丁咯地尔(Buflomedil)是一种血管活性制剂,可改善局部缺血区受损血管床的微循环。作者评价了慢性脑梗塞和轻至中度智力减退患者长期口服丁咯地尔对局部血流的影响。方法 10例病人,口服丁咯地尔150mg,一日3次,8周。治疗前和治疗最后一周测定脑局部血流量(rCBF),对照组病人(12例)间隔7~48天(20.3±11.9天)测定rC-BF。治疗前和最后一周进行简易智力记分和自我评价抑郁等级。
Buflomedil is a vasoactive agent that improves the microcirculation of the damaged vascular bed in the ischemic area. The authors evaluated the effect of long-term oral buflomedil on local blood flow in patients with chronic cerebral infarction and mild to moderate mental retardation. Methods Ten patients were given buflomedil 150 mg three times a day for 8 weeks. RCBF was measured before treatment and in the last week of treatment, and rC-BF was measured in control patients (12 patients) at intervals of 7 to 48 days (20.3 ± 11.9 days). Before and during the last week of simple mental score and self-evaluation of depression levels.