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目的：探讨参加乙酰化酶（ＮＡＴ２）分型试验的健康医学生志愿者的个性特征，为科学地理解和推广以医学生志愿者为被试进行的新药开发和临床药理学研究结果提供依据。方法：采用艾森克个性问卷（ＥＰＱ），对１１９名健康医学生志愿者的个性特征进行测查，并与对照组和全国常模比较。结果：志愿者的精神质（Ｐ）分存在显著的性别差异；志愿者与对照组的个性特征无明显差异；男、女志愿者的Ｐ和Ｌ分均显著低于常模，Ｎ分无明显差异，Ｅ分女性显著高于常模。结论：医学生志愿者的个性特征与一般人群有明显差异。在临床药理学研究中应重视被试者的个性特征及其对实验结果可能造成的影响。
OBJECTIVE: To investigate the personality characteristics of healthy volunteers who participated in the NAT2 typing test to provide scientific basis for the scientific understanding and promotion of new drug discovery and clinical pharmacology research conducted by volunteer students. Methods: Eysenck Personality Questionnaire (EPQ) was used to investigate the personality traits of 119 healthy volunteers and compared with the control group and the national norm. Results: There were significant gender differences in the psychotic (P) scores of the volunteers. There was no significant difference in the personality traits between the volunteers and the control group. The P and L scores of male and female volunteers were significantly lower than those of the norm Differences, E sub-female was significantly higher than the norm. Conclusion: The characteristics of medical student volunteers have obvious differences with the general population. In the clinical pharmacology research should pay attention to personality characteristics of the subjects and their possible impact on the experimental results.