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本文报道瑞士头孢三嗪在我国正常人的药代动力学研究。剂量为1g,静注和肌肉注射,2周后交叉注射。血及尿标本浓度均采用微生物法测定。研究结果显示,肌注和静注后药时曲线分别符合一室开放模型和二室开放模型。静注后即刻血浓度为316.56μg/ml;肌注后2小时血清峰浓度达155.47μg/ml,生物利用度完全。肌注和静注的消除半衰期分别为7.82和7.46小时,总表观分布容积分别为0.107L/kg和0.106L/kg。肌注后24小时自尿排出32％,静注后24小时自尿排出43％。
This article reports the Swiss pharmacokinetics of ceftriaxone in our country. The dose of 1g, intravenous and intramuscular injection, 2 weeks after the cross-injection. Blood and urine samples were determined by microbiological method. The results showed that intramuscular injection and intravenous injection after the drug curve were consistent with the open chamber model and two open chamber model. Immediate intravenous blood concentration was 316.56μg / ml; 2 hours after intramuscular injection of serum peak concentration of 155.47μg / ml, complete bioavailability. The elimination half-lives of intramuscular and intravenous injection were 7.82 and 7.46 hours, respectively, with a total apparent volume of distribution of 0.107 L / kg and 0.106 L / kg, respectively. 24 hours after intramuscular injection from the urine 32%, 24 hours after intravenous injection of urine from the 43%.