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自从诺埃尔(Nowell)和亨格福德(Hungerford)发现慢性粒细胞白血病(简称慢粒)存在着非随机重组的Ph染色体以来,迄今已有28年的历史。在这期间,广大血液学和遗传学工作者对慢粒与遗传学相关性的研究发生了浓厚的兴趣,并作了大量的深入细致的工作。随着遗传学技术的改善和发展,对慢粒的发病机制、诊断、预后和治疗的认识已逐步深入,并提高了临床水平。特别是近年来,同步化高分辨技术的应用,大大提高了Ph的检出率,发现了一些新的微小染色体异常,并对慢粒Ph肿瘤克隆的起源提出了新的认识,初步了解了慢粒急变的细胞遗传学机制,从而为今后的研究奠定了基础。
It has been 28 years since Noell and Hungerford found that there is a non-randomly recombined Ph chromosome in chronic myeloid leukemia (CML). During this period, the majority of hematology and genetics workers had a great interest in the research of the correlation between CGRP and genetics, and made a great deal of intensive and meticulous work. With the improvement and development of genetics technology, the understanding of the pathogenesis, diagnosis, prognosis and treatment of CML has been gradually deepened and the clinical level has been raised. Especially in recent years, the application of synchronized high-resolution technique has greatly increased the detection rate of Ph and found some new minor chromosomal abnormalities, and put forward a new understanding of the origin of slow-growing Ph tumor clones, initially understanding the slow Granulocyte cytopathic mechanism, which laid the foundation for future research.