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流行性脑膜炎在新兵中的发病率要比一般人群至少高4至10倍,尤其在入伍后前几周内。1985和1986年意大利新兵中C群脑膜炎球菌引起的脑膜炎分别占总病例数的92%和95%,所以作者从1987年开始,用A和C群脑膜炎球菌多糖混合菌苗对每年入伍新兵进行预防接种,除1987年接种15万人外,此后每年对所有30万新兵全部接种。为了解该混合菌苗诱导体液免疫应答的情况,作者对100名年龄为18～25岁新兵在免疫前和免疫
The prevalence of meningococcal meningitis in recruits is at least 4- to 10-fold higher than in the general population, especially in the first few weeks after enlistment. Meningitis caused by meningococcal group C in Italian recruits in 1985 and 1986 accounted for 92% and 95% of the total number of cases, respectively. Therefore, the authors enrolled each year in 1987 with group A and group C meningococcal polysaccharide mixed vaccine The new recruits were vaccinated. In addition to the 150,000 vaccinated in 1987, all 300,000 new recruits were vaccinated annually thereafter. To understand the mixed vaccine induced humoral immune response, the author of 100 aged 18 to 25-year-old recruits before immunization and immune