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目的:验证建立具有子宫内膜异位症复发风险大鼠模型的可行性及观察中药活血消异方对该模型种植灶体积变化、形态学变化的影响。方法:采用大鼠自体子宫皮下移植法造模,并在造模后第1天给药以模拟具有子宫内膜异位症复发风险的环境,大体及光镜下观察各组大鼠种植灶体积及内膜组织形态的变化。结果:中药组种植灶体积在给药3周时及停药3周后,与模型组比较,差异均有统计学意义(P<0.05);中药组异位内膜的腺上皮细胞扁平,腺腔较小,间质内腺体数量减少。结论:建立大鼠内异症模型并在造模后第1天给药,这种模拟内异症复发风险环境的方法具有可行性;中药活血消异方对异位包块的复发具有良好的、较持久的抑制作用。
OBJECTIVE: To verify the feasibility of establishing a rat model of recurrent endometriosis and to observe the effect of Huoxuexian Fang on the volume change and morphological changes of the model foci. Methods: The rat model of subcutaneous autologous uterus transplantation was established and administered on the first day after modeling to simulate the environment with the risk of recurrent endometriosis. The volume of the implant in each group was observed under light microscope And changes in the morphology of endometrial tissue. Results: The volume of the foci in the Chinese medicine group was statistically significant (P <0.05) compared with the model group at 3 weeks and 3 weeks after drug withdrawal. The glandular epithelial cells in the ectopic endometrium of the TCM group were flat and glandular Cavity smaller interstitial glands reduce the number. Conclusion: The model of rat endometriosis is established and administered on the first day after modeling. This method of simulating endometriosis relapse risk environment is feasible. The traditional Chinese medicine Huoxuexian Fang has good effect on the recurrence of ectopic mass , More durable inhibition.