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目的 对慢性阻塞性肺疾病 (COPD)急性发作期患者及急性肺炎患者的血小板活化指标进行比较与研究。方法 应用流式细胞术检测 6 0例COPD急性发作期患者和 48例急性肺炎患者的P 选择素 (CD6 2P)、血小板膜糖蛋白 5 3(CD6 3)、血小板膜糖蛋白Ⅲa(CD6 1)和血小板膜糖蛋白Ⅱb(CD41)血小板表面的表达并与 2 0例健康成人所测结果进行对照。结果 CD6 1与CD41、CD6 2P、CD6 3呈正相关 ,CD6 2P和CD6 3呈正相关。CD6 2P、CD6 3的表达在COPD急性发作期患者与急性肺炎患者之间无明显差异 ,但两组均显著高于正常对照组。结论 CD6 2P、CD6 3在COPD患者急性发作期及急性肺炎均有升高。提示COPD急性发作期及急性肺炎存在血小板活化现象
Objective To compare and study the platelet activation index in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) and acute pneumonia. Methods Flow cytometry was used to detect the expression of P-selectin (CD6 2P), platelet membrane glycoprotein 5 3 (CD6 3), platelet membrane glycoprotein Ⅲ a (CD6 1) in 60 COPD patients with acute exacerbation and 48 patients with acute pneumonia. And platelet membrane glycoprotein Ⅱ b (CD41) platelet surface expression and with 20 healthy adults measured results were compared. Results CD6 1 was positively correlated with CD41, CD6 2P and CD6 3, while CD6 2P and CD6 3 were positively correlated. CD6 2P, CD6 3 expression in patients with acute exacerbation of COPD and acute pneumonia no significant difference between patients, but both were significantly higher than the normal control group. Conclusions Both CD6 2P and CD6 3 are elevated in acute exacerbation and acute pneumonia in COPD patients. Tip acute exacerbation of COPD and acute platelet activation in patients with pneumonia