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我院自1986年6月至1989年6月检查了634例病人的胃粘膜,从幽门弯曲菌(CP)的细菌学、致病性、病理学、诊断方法及药物治疗等方面进行了研究,探讨CP与慢性胃炎及消化性溃疡的关系。结果发现CP有两种形态并与空弯菌不同,不产生肠毒素;消化性溃疡的CP检出率为80.9％,慢性胃炎为41.6％,显著高于正常胃粘膜(3.7％);CP与消化性溃疡、慢性胃炎,十二指肠炎特别是活动性炎症有密切关系;CP对胃型上皮或粘液有某种亲和性;观察到上皮细胞破溃处有大量细菌聚集,CP有致细胞病变的能力。用阿的平代替吖啶橙荧光染色,并制成CP感染快速诊断试剂盒。呋喃唑酮促进溃疡愈合,使45～73％病例CP消失,50～70％胃炎好转。但有复发,根除CP有困难。
Our hospital from June 1986 to June 1989 examined 634 patients with gastric mucosa, Campylobacter pylori (CP) bacteriology, pathogenicity, pathology, diagnostic methods and drug treatment were studied, To investigate the relationship between CP and chronic gastritis and peptic ulcer. The results showed that CP had two kinds of morphology and different from Curculigo, which did not produce enterotoxin. The detection rate of CP in peptic ulcer was 80.9% and chronic gastritis was 41.6%, which was significantly higher than that in normal gastric mucosa (3.7%). CP and Peptic ulcer, chronic gastritis, duodenal inflammation, especially active inflammation are closely related; CP on gastric epithelial or mucus have some affinity; observed epithelial cell rupture at a large number of bacterial aggregation, CP have cytopathic effect Ability. Flunarizine was used instead of acridine orange fluorescence staining, and made CP infection rapid diagnostic kit. Furazolidone to promote ulcer healing, 45 ~ 73% of cases CP disappeared, 50 to 70% gastritis improved. However, recurrence, CP eradication difficulties.