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目的观察加速度（＋ＧＺ）作用后血清中尿素氮（ＢＵＮ）、肌酐（Ｃｒ）、碱性磷酸酶（ＡＫＰ）、β２－微球蛋白（β２－Ｍ）和Ｃａ２＋浓度及肾脏病理改变。方法４８只雄性大鼠随机分为４组，每组１２只。地面未受附加＋ＧＺ暴露为Ａ组，受＋１ＧＺ为Ｂ组，＋１０ＧＺ为Ｃ组和Ｄ组。Ｂ组与Ｃ组在第３次加速度作用（每次３ｍｉｎ，间隔４０ｍｉｎ，共３次）后１０ｍｉｎ处死。Ｄ组在２４ｈ后处死，测上述指标。结果以Ｂ组为对照组，Ｃ组ＢＵＮ有显著增高（Ｐ＜０．０１）。Ｄ组Ｃａ２＋、β２－Ｍ有明显升高（Ｐ＜０．０５）。ＢＵＮ是恢复至正常最快的肾功能指标。受＋１０ＧＺ重复作用后，光镜下见肾脏血管呈收缩改变，电镜下见肾小球及肾小管的细胞、线粒体有病理改变。结论＋１０ＧＺ的重复暴露对大鼠肾脏功能和结构都有损害。
Objective To observe the serum levels of BUN, creatinine (AKP), β2-microglobulin (β2-M) and Ca2 + and the pathological changes of kidney after acceleration (+ GZ). Methods Forty-eight male rats were randomly divided into 4 groups with 12 rats in each group. The ground was exposed without additional + GZ as group A, + 1GZ as group B and + 10GZ as group C and group D. Rats in group B and group C were sacrificed 10 min after the third acceleration (3 min each, 40 min intervals). Group D was sacrificed after 24h, measuring the above indexes. The results of group B as control group, C group BUN was significantly higher (P <0.01). D group Ca2 +, β2-M were significantly increased (P <0.05). BUN is restored to the normal renal function indicators the fastest. Repeated by +10 GZ, see the light microscope, the contraction of renal blood vessels showed changes under the electron microscope, glomerular and tubular cells, mitochondria pathological changes. Conclusions Repeated +10 GZ exposure impaired the function and structure of rat kidneys.