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目的探讨无(弱)应答的医院职工接种60μg乙肝疫苗后的抗体产生状况及其影响因素。方法在深圳市某医院既往接受过乙肝疫苗0、1、6程序接种而未产生保护性抗体的职工中,随机抽取研究对象,使用深圳康泰生物制品股份有限公司生产的60μg重组乙型肝炎(酿酒酵母)疫苗再次接种,5个月后采集接种者血清,采用化学发光免疫分析法(CLIA法)检测抗-Hbs水平。同时对接种者进行问卷调查,采用非条件Logistic回归分析,以了解影响乙肝疫苗免疫应答的因素。结果本次调查共发出问卷110份,收回有效问卷102份,有效回收率为92.73%。接种后,乙肝抗体阳转率达100.0%,乙肝保护性抗体阳转率达88.24%。非条件Logistic回归分析未发现影响接种乙肝疫苗无(弱)应答率的因素(P>0.05)。结论低/无应答者接种一针高剂量60μg乙肝疫苗,可获得较好抗体应答。尚未发现影响接种乙肝疫苗无(弱)应答率的因素。
Objective To investigate the antibody production status and its influencing factors of hospital staff without (weak) response to inoculation of 60 μg hepatitis B vaccine. Methods In a hospital in Shenzhen in the past received hepatitis B vaccine 0,1,6 routine vaccination without protective antibodies in workers randomly selected subjects, the use of Shenzhen Kangtai Biological Products Co., Ltd. production of 60μg recombinant hepatitis B Yeast) vaccine was inoculated again. After 5 months, the sera of the vaccinates were collected and the level of anti-Hbs was detected by chemiluminescence immunoassay (CLIA method). At the same time, a questionnaire survey was conducted on the vaccinators, using non-conditional Logistic regression analysis to understand the factors that affect the immune response of hepatitis B vaccine. Results A total of 110 questionnaires were sent out and 102 valid questionnaires were recovered. The effective recovery rate was 92.73%. After inoculation, hepatitis B antibody positive rate of 100.0%, hepatitis B protective antibody positive rate of 88.24%. Non-conditional Logistic regression analysis found no factors influencing the no (weak) response rate of hepatitis B vaccine (P> 0.05). Conclusions Low / non-responders were vaccinated with a high dose of 60 μg hepatitis B vaccine to obtain better antibody response. No factors influencing the (no) response to hepatitis B vaccine have not been found.