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目的：观察头孢唑林联合肝素封管在预防血液透析导管相关性感染的疗效。方法：将2010年1月至2014年5月使用长期透析导管进行维持性血液透析的终末期肾病患者42例随机分为观察组和对照组各21例，观察组使用头孢唑林（50 mg／ml）加肝素生理盐水（3000 u／ml）封管，对照组仅使用肝素生理盐水（3000 u／ml ）封管，连续观察6个月，比较两组导管相关性感染的发生情况。结果：两组患者均未出现导管出口感染及皮下隧道感染。观察组无1例发生导管相关血流感染（CRBSI），对照组出现6例次导管相关性菌血症，两组长期导管感染发生率有显著差异（P＜0．05）。结论：与单纯肝素封管相比，头孢唑林联合肝素封管可显著降低导管相关性血流感染发生率。“,”Objective: To investigate curative effect of preventing tunneled catheter-related infections by using Cefazolin-Heparin locking solutions in hemodialysis. Methods: From January 2010 to May 2014, 42 cases underwent hemodialysis were randomly divided into research group (n=21) and control group (n=21). Cefazolin (50 mg/ml) combined with Heparin(3000 u/ml)and just Heparin(3000 u/ml)solution was filled in catheter lumens at the end of each hemodialysis session in treatment group and control group respectively. Incidence of infections about the two groups was compared after a continuous observation for 6 months. Results: Exit site or tunnel infection was not occurred in each group but 6 patients developed catheter-related bloodstream infection (CRBSI) in control group. There was no CRBSI occurred in treatment group and the different incidence of CRBSI between the two groups was significant (P<0.05). Conclusion: Comparing with Heparin solution only of catheter-restricted filling, Cefazolin and Heparin may significantly reduce the incidence of catheter-related bloodstream infection in hemodialysis.