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乙双吗啉治疗银屑病诱发急性白血病的报道已较多。但同时诱发另一恶性肿瘤者国内尚未见报道。现报道1例如下: 患者,男,49岁。患银屑病近20年。自1984年起,服用乙双吗啉治疗(每天0.4～0.6g,总剂量500g左右)。无吸烟嗜好,无慢性呼吸道疾病史。入院前半个月出现发热,鼻衄,乏力。于1988年12月18日住院。查体:T38℃,P90次/分,R20次/分,BP14.7/10.7 kPa。中度贫血貌。全身皮肤未见出血斑点,四肢躯干皮肤散在脱屑皮疹。浅表淋巴结未触及。气管居中。胸骨中下段压痛。心肺听诊(一)。腹软,肝脾肋下均未触及。胫骨无压痛。血红蛋白75g/L,白细胞2×10~9/L,中性20％,淋巴26％,幼稚细胞54％,网织红0.2％,血小板60×10~9/L。骨髓增生极度活跃,原粒0％,早
B-morphine treatment of psoriasis-induced acute leukemia has been more reported. But at the same time induce another malignant tumor in China has not been reported. 1 case is reported as follows: patients, male, 49 years old. Psoriasis for nearly 20 years. Since 1984, taking bomorphine treatment (0.4 ~ 0.6g per day, the total dose of 500g or so). No smoking habits, no history of chronic respiratory disease. Half a month before admission fever, epistaxis, fatigue. In December 18, 1988 hospitalization. Physical examination: T38 ℃, P90 beats / min, R20 beats / min, BP14.7 / 10.7 kPa. Moderate anemia appearance. No bleeding spots on the whole body skin, limbs and trunk skin scattered in the desquamation rash. Superficial lymph nodes not touched. Tracheal center. Sternum in the lower tenderness. Cardiopulmonary auscultation (a). Abdominal soft, liver and spleen are not touched under the ribs. Tibia no tenderness. 75g / L hemoglobin, 2 × 10 ~ 9 / L white blood cells, 20% neutral, 26% lymphoid, 54% naive cells, 0.2% reticulocyte and 60 × 10 ~ 9 / L platelets. Myeloid hyperplasia is extremely active, 0% of the original particles, early