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异烟肼为30多年来广泛用于结核病治疗的第一线抗结核药。近年临床用于非结核治疗的报道也不断出现,现将其临床新用途综合如下。一、治疗急性菌痢:异烟肼时痢疾杆菌有明显的抗菌作用,其机制可能为抑制细菌氨基酸代谢。阎氏药敏实验证实,异烟肼对宋内氏痢疾杆菌、志贺氏痢疾杆菌、福氏痢疾杆菌、鲍氏痢疾杆菌等均有不同程度的抑制作用。对56例菌痢和肠炎患者,每次口服异烟肼0.2 g,维生素 B_6 10mg,每日3次治疗,结果于服药2天后脓血便消失,大便次数减少。服药4天后,大便转正常。56例中菌痢14例,经用药后治愈13例,1例无数;
Isoniazid is the first-line anti-tuberculosis drug widely used in the treatment of tuberculosis for more than 30 years. In recent years, clinical reports of non-tuberculosis treatment are also emerging, now its clinical new uses are summarized as follows. First, the treatment of acute bacillary dysentery: Isoniazid dysentery bacilli have obvious antibacterial effect, the mechanism may be to inhibit bacterial amino acid metabolism. Yan drug sensitive experiments confirmed that isoniazid on Shigella sonnei Shigella, Shigella dysenteriae, Shigella flexneri, Shigella dysenteriae Dengjun have different levels of inhibition. 56 patients with bacillary dysentery and enteritis, each oral isoniazid 0.2 g, vitamin B_6 10mg, 3 times a day treatment, the results in 2 days after taking pus and blood will disappear, stool frequency decreased. 4 days after taking the stool to normal. 56 cases of bacillary dysentery in 14 cases, after treatment, 13 cases were cured, 1 case of numerous;