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女婴、7天、因全身皮肤黄染频吐;啼哭不休、腹胀而就医。其母在妊娠9个月患急性重症肝炎、检测HBsAg、HBeAg、抗HBCIgM均阴性,生产时因大出血而死亡。体检:发育营养一般,皮肤巩膜明显黄软、颈软,心肺(-)肝肋下1cm、质中,脾未及、腹膨隆、腹水症(±),实验室检查:TTT12~u、 TFT+++、SCTPT120~u总胆红质342μmol/L、HBV标志检查(ELISA法)HBsAg(+)、HBeAg(+)、抗HBC-IgM(+)。诊断为先天性乙型肝炎。经保肝、抗病毒及支持疗法3天死亡。部腹见肝脏为综红黄色、表而肿胀且光滑、体积10.2×5.8×3.8cm。病理检查示肝
Baby girl, 7 days, due to body yellow hair spit; cry endlessly, abdominal distension and medical treatment. His mother had acute severe hepatitis at 9 months of gestation. The HBsAg, HBeAg, and anti-HBC IgG were all negative, and died of major bleeding during the production. Physical examination: General nutrition, sclera was soft yellow, neck soft, heart and lung (-) 1cm under the liver ribs, the quality of the spleen and abdominal bulging, ascites (±), laboratory tests: TTT12 ~ u, TFT +++, SCTPT120 ~ u total bilirubin 342μmol / L, HBV markers (ELISA) HBsAg (+), HBeAg (+), anti-HBC-IgM (+). Diagnosis of congenital hepatitis B. After liver protection, antiviral and supportive therapy died in 3 days. Abdominal see the liver for comprehensive red yellow, swollen table and smooth, volume 10.2 × 5.8 × 3.8cm. Pathological examination showed the liver