论文部分内容阅读
目的运用meta分析评估扩大根治术及标准根治术治疗胰头癌的远期疗效。方法检索Pubmed、WOS、Embase、万方、中国生物医学文摘及中国知网数据库1990~2012年期间的相关文献,运用Jadad评分评估所涉文献的研究质量。治疗组为胰头癌扩大根治术后患者,对照组为标准根治术后患者,运用meta分析评估2组患者的死亡率、并发症发生率,以及术后1、3及5年生存率的差异。结果 11篇文献入选,纳入病例744例,其中标准根治组357例,扩大根治组387例。结果显示:①2组患者术后并发症发生率的差异无统计学意义(OR=1.360,95%CI=0.990~1.870,P=0.050)。②2组患者术后死亡率的差异无统计学意义(OR=0.870,95%CI=0.430~1.760,P=0.700)。③2组患者术后1、3及5年生存率的差异均无统计学意义(OR=0.880,95%CI=0.450~1.720,P=0.710;OR=0.940,95%CI=0.590~1.480,P=0.710;OR=1.000,95%CI=0.600~1.670,P=1.000)。结论同标准根治术相比,扩大根治术不能改善患者术后1、3及5年生存率,不能降低死亡率及术后并发症发生率。
Objective To evaluate the long-term efficacy of extended radical mastectomy and standard radical mastectomy in the treatment of pancreatic head cancer using meta-analysis. Methods The related literatures of Pubmed, WOS, Embase, Wanfang, China Biomedical Digest and CNKI database from 1990 to 2012 were searched, and the quality of the research was evaluated by Jadad score. The treatment group was extended pancreatic cancer patients after radical mastectomy, and the control group was treated by standard radical mastectomy. Meta-analysis was used to evaluate the mortality, complication rates and 1,3 and 5-year survival rates . Results A total of 11 articles were included and included 744 cases, of which 357 cases were in the standard radical group and 387 cases in the radical group. The results showed that there was no significant difference in the incidence of postoperative complications between the two groups (OR = 1.360, 95% CI = 0.990-1.870, P = 0.050). ② There was no significant difference in postoperative mortality between the two groups (OR = 0.870, 95% CI = 0.430 ~ 1.760, P = 0.700). There was no significant difference in 1,3 and 5-year survival rates between the two groups (OR = 0.880, 95% CI = 0.450-1.720, P = 0.710; OR = 0.940, 95% CI = 0.590-1.480, P = 0.710; OR = 1.000, 95% CI = 0.600-1.670, P = 1.000). Conclusion Compared with standard radical mastectomy, extended radical mastectomy can not improve the 1,3-and 5-year survival rate of patients after surgery, can not reduce the mortality and postoperative complications.