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一、氨基糖甙类的抗菌活性〔1、2〕氨基糖甙类的抗菌谱较广,对革兰阴性杆菌及一些阳性菌均具抗菌活性,但其主要拮抗对象为肠杆菌科细菌、绿脓杆菌和金葡菌,链霉素对结核杆菌也具相当作用,附表示为氨基糖甙类对重要致病菌的抗菌作用比较.从表中可以看出;庆大霉素、妥布霉素、丁胺卡那霉素等不仅对大肠杆菌、肺炎杆菌、产气杆菌、吲哚阳性和阴性变形杆菌、沙门氏菌、痢疾杆菌等具相当抗菌活性,对一些比较耐药的条件致病菌如绿脓杆菌、产碱杆菌、不动杆菌属(多形模仿菌、硝酸盐阴性杆菌等)、枸橼酸杆菌、沙雷氏菌、阴沟杆菌等也有较好抗菌作
First, the antimicrobial activity of aminoglycosides [1,2] Aminoglycosides antibacterial spectrum of a wide range of Gram-negative bacilli and some positive bacteria have antibacterial activity, but its main antagonist for Enterobacteriaceae bacteria, green Staphylococcus aureus and Staphylococcus aureus, streptomycin on tuberculosis also have a considerable role, attached as aminoglycosides antibacterial effect on important pathogenic bacteria comparison can be seen from the table; gentamicin, tobramycin Klebsiella, such as kanamycin, not only for E. coli, Klebsiella pneumoniae, Aerobacter aerogenes, indole-positive and negative Proteus, Salmonella, Shigella and other antibacterial activity with considerable resistance to some of the more resistant to opportunistic pathogens such as Pseudomonas aeruginosa, Alcaligenes, Acinetobacter (polymorphic mimic bacteria, nitrate-negative bacilli, etc.), Citrobacter, Serratia, cloacae, etc. also have good antibacterial