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目的:比较PVB与PF方案对局部晚期宫颈癌患者PTEN、VEGF和CD105表达的影响。方法:选取我院妇科收治的局部晚期宫颈癌患者150例,随机分为两组,其中PVB组75例予顺铂、长春新碱、博来霉素化疗;PF组75例予博来霉素、顺铂配合5-氟尿嘧啶治疗。观察并对比治疗前后患者临床疗效及患者癌组织PTEN、VEGF表达阳性率、CD105抗体标记的肿瘤MVD值等指标。结果:1治疗后两组PTEN、VEGF表达阳性率均有所改善,与PVB组(76.3%)比较,PF组PTEN表达阳性率(88.3%)明显升高,差异有统计学意义(P<0.05);与PVB组(15.3%)比较,PF组VEGF表达阳性率(6.7%)明显降低,差异有统计学意义(P<0.05);2治疗后两组MVD值均有所改善,与PVB组(38.93±9.89)比较,PF组MVD值(35.61±10.33)明显降低,差异有统计学意义(P<0.05);3治疗后,与PVB组(76.67%)比较,PF组的有效率(86.67%)明显较高,差异有统计学意义(P<0.05)。结论:与PVB方案相比,PF方案能够使局部晚期宫颈癌患者PTEN表达水平升高,降低VEGF和CD105表达水平,临床疗效更确切。
Objective: To compare the effects of PVB and PF on the expression of PTEN, VEGF and CD105 in patients with locally advanced cervical cancer. Methods: 150 cases of locally advanced cervical cancer treated by gynecology in our hospital were randomly divided into two groups, of which 75 cases were treated with cisplatin, vincristine and bleomycin in PVB group and 75 cases with bleomycin , Cisplatin with 5-fluorouracil treatment. To observe and compare the clinical efficacy of patients before and after treatment and the positive rate of PTEN, VEGF expression in cancer patients, CD105 antibody labeled MVD values and other indicators. Results: The positive rates of PTEN and VEGF in both groups were improved after treatment. Compared with PVB group (76.3%), the positive rate of PTEN expression in PF group was significantly higher (88.3%), the difference was statistically significant (P <0.05 ). Compared with PVB group (15.3%), the positive rate of VEGF expression in PF group (6.7%) was significantly lower than that in PVB group (P <0.05); MVD was improved in both groups after treatment, (38.93 ± 9.89), the MVD in PF group (35.61 ± 10.33) was significantly lower than that in PVB group (76.67%), the difference was statistically significant (P <0.05) %) Was significantly higher, the difference was statistically significant (P <0.05). Conclusion: Compared with PVB regimen, PF regimen can increase PTEN expression in patients with locally advanced cervical cancer and decrease the expression of VEGF and CD105. The clinical effect is more accurate.