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目的探讨乳腺癌患者血清甲状腺激素水平的变化及其临床意义。方法回顾性分析30例乳腺癌患者的血清中甲状腺激素水平,并与同期30例健康人群作对比。结果乳腺癌患者血清T3和FT3值均明显降低,与正常对照组相比有统计学意义(P<0.05);T4和FT4值轻度降低,但与对照组无显著性差异(P>0.05),TSH值无明显变化(P>0.05);Ⅲ、Ⅳ期乳腺癌患者T3和FT3值显著低于Ⅰ、Ⅱ期乳腺癌患者(P<0.05),而以年龄、肿瘤直径、ER、PR、Her2表达水平分组中血清甲状腺激素水平的变化无显著差异性(P>0.05)。结论乳腺癌患者血清甲状腺激素水平与患者的病情严重程度相关,监测血清甲状腺激素可有助于评估病情和判断预后。
Objective To investigate the changes of serum thyroid hormone in patients with breast cancer and its clinical significance. Methods The serum levels of thyroid hormone in 30 patients with breast cancer were retrospectively analyzed and compared with 30 healthy people in the same period. Results The serum levels of T3 and FT3 in patients with breast cancer were significantly lower than those in normal controls (P <0.05), while the values of T4 and FT4 in patients with breast cancer were slightly lower than those in controls (P> 0.05) (P> 0.05). The T3 and FT3 values of stage Ⅲ and Ⅳ breast cancer patients were significantly lower than those of stage Ⅰ and Ⅱ breast cancer patients (P <0.05), but the age, tumor diameter, ER, PR, There was no significant difference in serum thyroid hormone level in Her2 expression group (P> 0.05). Conclusion Serum thyroid hormone levels in patients with breast cancer are related to the severity of the disease. Monitoring serum thyroid hormone may be helpful in assessing the prognosis and prognosis.