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肝组织的超微结构观察对探讨慢性病毒性肝炎和肝炎后肝硬变中肝损伤的发生机理和发展规律有重要意义。虽然有些超微结构改变是非特异的,但有某些改变对慢性肝病的诊断和分型可能有一定意义,对治疗也可能有某些启示。现将有关情况分述如下。一、慢性迁延性肝炎(慢迁肝) 1.肝细胞的超微病理改变:慢迁肝的炎症反应主要在汇管区。与汇管区炎性细胞相接近的肝细胞有比较明显的亚细胞改变,但并不严重,其主要变化是内质网轻度扩张,胞浆内脂滴增多。少量肝细胞有气球样变性,其内质网扩张较明显。嗜酸性小体很少见,每个肝小叶内只有1～2个。气球样改变则呈明显的肝细胞内质网高度扩张,糖
Ultrastructural observation of liver tissue is of great significance in exploring the pathogenesis and development of liver damage in chronic viral hepatitis and posthepatitic cirrhosis. Although some ultrastructural changes are nonspecific, some changes may have implications for the diagnosis and typing of chronic liver disease and may have some implications for treatment. Now the relevant points are as follows. First, chronic persistent hepatitis (slow migration of liver) 1. Ultra-pathological changes of liver cells: the slow-moving liver inflammation mainly in the portal area. The hepatocytes close to the inflammatory cells in the portal area had obvious subcellular changes, but not serious ones. The main changes were the mild expansion of the endoplasmic reticulum and the increase of intracellular lipid droplets. A small number of hepatocytes balloon degeneration, the more obvious expansion of the endoplasmic reticulum. Eosinophilic body is rare, only 1 to 2 within each hepatic lobule. Balloon-like changes were significantly higher endoplasmic reticulum hepatocyte expansion, sugar