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近年来,关于急性心肌梗塞(AMI)的发病原理,形成了一系列新的概念。这些概念多数已被实验研究和临床观察所提供的客观依据证实。目前认为,在有或无冠状动脉粥样硬化病变条件下,凡能造成心肌氧供需平衡失调的因素,例如冠脉血流量减少及/或心肌细胞代谢需要增加时,皆能产生心肌缺血;如果程度严重,持续时间过久,而且造成缺血的根本原因未被解除,终将造成不可逆性心肌损害和心肌梗塞。病理生理基础,以冠脉粥样硬化和冠脉痉挛最重要。心肌缺血的原因,大多数是心外膜冠脉粥样硬化斑块使管腔狭窄,在血流量减少情况下发生了心肌需氧量增加。冠状动脉血栓形成心肌细胞急性坏死的首要因素,是在冠脉粥样硬化性损害基础上发生急性管腔阻塞,导致心肌氧
In recent years, on the pathogenesis of acute myocardial infarction (AMI), formed a series of new concepts. Most of these concepts have been corroborated by objective evidence provided by experimental studies and clinical observations. Currently, with or without coronary atherosclerotic lesion conditions, those who cause myocardial imbalance in oxygen supply and demand factors such as decreased coronary blood flow and / or increased myocardial cell metabolism, can produce myocardial ischemia; If the degree is serious, the duration is too long, and the underlying cause of ischemia is not lifted, will eventually cause irreversible myocardial damage and myocardial infarction. Pathophysiology, with coronary atherosclerosis and coronary artery spasm most important. The cause of myocardial ischemia, most of the epicardial coronary atherosclerosis plaque to narrow the lumen, myocardial blood oxygen demand increased in the case of reduced blood flow. Coronary thrombosis cardiomyocytes acute necrosis is the primary factor in coronary atherosclerotic lesions based on the occurrence of acute lumen obstruction, leading to myocardial oxygen