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目的分析新疆乌鲁木齐市某医院妇科门诊就诊者高危型人类乳头状瘤病毒(HPV)感染与梅毒螺旋体(TP)之间的相关性。方法采用二代杂交捕获法对妇科门诊2 061名就诊者进行高危型HPV检测;采用ELISA(初筛)和梅毒螺旋体明胶颗粒凝集试验(确诊)对618例阳性者和979例非高危型HPV感染者进行梅毒螺旋体的血清学检查。结果 2 061名就诊者高危型HPV感染率为29.99%,年龄因素与高危型HPV感染率之间存在关联(r=0.168),以41～50岁年龄段高危型HPV阳性率最高;618例高危型HPV感染者TP阳性率10.68%,979例非高危型HPV感染者TP阳性率3.78%。高危型HPV感染者中,年龄因素和民族因素都与TP阳性率有相关性(r年龄=0.131,r民族=0.174),以41～50岁年龄段维吾尔族人群TP阳性率最高。结论本研究提供了新疆地区某医院妇科门诊就诊人群中高危型HPV和TP感染的流行病学数据。证明在妇科门诊就诊人群中高危型HPV感染与TP感染具有相关性。
Objective To analyze the correlation between high-risk human papilloma virus (HPV) infection and Treponema pallidum (TP) in gynecology clinic of a hospital in Urumqi, Xinjiang. Methods High-risk HPV was detected in 2 061 outpatients in the outpatient department of gynecology by second-generation hybridization capture method. 618 positive cases and 979 non-high-risk HPV cases were detected by ELISA (initial screening) and Treponema pallidum gelatin particle agglutination test Serological examination of Treponema pallidum. Results The prevalence of high-risk HPV infection was 29.99% in 2 061 patients. There was a correlation between age and high-risk HPV infection (r = 0.168). The highest prevalence was high-risk HPV in 41-50 age group The positive rate of TP in type HPV was 10.68%. The positive rate of TP in 979 non-type HPV was 3.78%. In high-risk HPV infection, age-related and ethnic factors were correlated with the positive rate of TP (r = 0.131, r = 0.174). The highest positive rate was observed in Uyghur from 41 to 50 years old. Conclusions This study provides epidemiological data on high-risk HPV and TP infections in gynecology outpatient clinics in a hospital in Xinjiang. It is proved that high-risk HPV infection is associated with TP infection in gynecological clinic.