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目的探讨肺鳞状上皮细胞癌(鳞癌)患者手术前后血清细胞角蛋白19片段(CYFRA21-1)水平变化。方法采用双抗体夹心磁微粒化学发光法检测行手术治疗Ⅰ~Ⅲa期原发性肺鳞癌患者(A组,41例)手术前后以及同期住院Ⅲb期和Ⅳ期未行手术治疗的肺鳞癌患者(B组,37例)、健康体检者(C组,36例)血清CYFRA21-1水平。结果B组血清CYFRA21-1水平高于A组术前水平[(21.3±9.4)ng/ml vs.(12.4±3.9)ng/ml](P<0.01),且A组术前及B组血清CYFRA21-1水平均高于C组的(1.3±1.5)ng/ml(P<0.01)。A组术后第7天和术后第30天的血清CYFRA21-1水平均低于术前[(4.1±1.6)ng/ml和(1.8±1.1)ng/ml vs.(12.4±3.9)ng/ml](P<0.01),术后第30天血清CYFRA21-1水平亦低于术后第7天(P<0.01)。结论肺鳞癌患者血清CYFRA21-1高表达,手术可显著降低肺鳞癌患者血清CYFRA21-1水平。血清CYFRA21-1水平变化可作为辅助评价肺鳞癌患者手术疗效的指标。
Objective To investigate the changes of serum cytokeratin 19 (CYFRA21-1) levels in patients with squamous cell carcinoma (squamous cell carcinoma) before and after operation. Methods The double antibody sandwich magnetic particle chemiluminescence was used to detect the patients with primary squamous cell carcinoma of stage Ⅰ-Ⅲa (group A, n = 41) before and after operation and in stage Ⅲb and Ⅳ of the same period without surgical treatment Patients (group B, 37 cases), healthy subjects (group C, 36 cases) serum CYFRA21-1 levels. Results The level of serum CYFRA21-1 in group B was significantly higher than that in group A [(21.3 ± 9.4) ng / ml vs. (12.4 ± 3.9) ng / ml] (P <0.01) CYFRA21-1 levels were higher than those in C group (1.3 ± 1.5) ng / ml (P <0.01). The serum levels of CYFRA21-1 on the 7th day and the 30th day after operation in group A were lower than those in preoperative [(4.1 ± 1.6) ng / ml and (1.8 ± 1.1) ng / ml vs. (12.4 ± 3.9) ng / ml] (P <0.01). The level of serum CYFRA21-1 on the 30th day was also lower than that on the 7th day (P <0.01). Conclusion The expression of CYFRA21-1 in patients with squamous cell carcinoma is highly expressed, and the serum CYFRA21-1 levels in patients with squamous cell carcinoma can be significantly reduced by surgery. Serum CYFRA21-1 levels can be used as a secondary evaluation of surgical treatment of patients with squamous cell carcinoma of the index.