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充血性心力衰竭(CHF)使用β阻滞剂因负性变力性效应而受限,但其血管扩张特性却有助于克服之。以卡维地洛(Carvedilol)估价17例继发于缺血性心脏病的慢性 CHF 患者。休息时左室射血分数≤45％,运动时行放射性心室造影术和右心导管术测定卡维地洛治疗(剂量12.5～50.0mg,每日两次)8周前后的动脉内压。完成研究12例中11例症状和血流动力学改善,长期治疗心率和动脉内压均减低。运动时间差4.3±1.6至7.1±2.7分
The use of beta blockers in patients with congestive heart failure (CHF) is limited by the negative variability effect, but its vasodilator properties help to overcome it. Seventeen patients with chronic CHF secondary to ischemic heart disease were evaluated with Carvedilol. Left ventricular ejection fraction ≤ 45% at rest, exercise intravenous radiography and right heart catheterization of carvedilol treatment (dose 12.5 ~ 50.0mg, twice daily) before and after 8 weeks of arterial pressure. Eleven patients completed the study in 11 patients with symptoms and hemodynamic improvement, long-term treatment of heart rate and arterial pressure were reduced. Movement time difference of 4.3 ± 1.6 to 7.1 ± 2.7 points