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目的及时发现乙肝病毒(HBV)感染者中的肝癌患者,探讨HBV感染者肝功能与肝癌发病的关系。方法对2008年兖州6个铁路单位20~60岁健康体检职工中检出的HBV感染者485名,每半年进行一次肝功能、甲胎球蛋白(AFP)检测和肝脏B超检查随访,观察肝癌发病情况。结果 2008~2012年12月31日,485名HBV感染者中,18人经AFP和(或)肝脏B超检查确诊为肝癌,肝癌累积发病率为3.71%。肝癌累积发病率,肝功正常者420人为1.43%,肝功异常者65人为18.46%(P<0.01);20~40岁225人为1.78%,41~60岁260人为5.38%(P<0.05)。2008~2012年(观察第一年、第二年、第三年、第四年、第五年内),485名HBV感染者肝癌发病率分别为0.62%、0.21%、0.62%、1.03%、1.24%。结论 HBV感染者中肝功异常者容易发生肝癌,高年龄组尤为明显。
Objective To detect liver cancer patients with hepatitis B virus (HBV) infection in time and explore the relationship between liver function and the incidence of liver cancer in HBV infected patients. Methods A total of 485 HBsAg positive HBV carriers were detected in 6 health workers in 20 railways aged 60-60 years in Yanzhou in 2008. Liver function, AFP and liver ultrasonography were followed up every 6 months. Liver cancer Incidence. Results From December 2008 to December 31, 2012, 18 out of 485 HBV infected patients were diagnosed as HCC by AFP and / or B-ultrasound. The cumulative incidence of HCC was 3.71%. The cumulative incidence of liver cancer was 1.43% in normal persons with normal liver function, 18.46% in 65 patients with abnormal liver function (P <0.01), 1.78% in 225 patients aged 20-40 years and 5.38% in 260 persons aged 41-60 years (P <0.05) . The incidence of hepatocellular carcinoma in 485 HBV infected patients was 0.62%, 0.21%, 0.62%, 1.03% and 1.24 respectively from 2008 to 2012 (the first year, second year, third year, fourth year and fifth year) %. Conclusion Hepatic cancer is more likely to occur in patients with abnormal liver function in HBV infected persons, especially in the high age group.