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采用雄性昆明种小鼠和Wistar大鼠。250只小鼠分为五组:(1)2-AAQ高剂量组(2000毫克/公斤);(2)2-AAQ低剂量组(400毫克/公斤);(3)联苯胺阳性对照组(150毫克/公斤);(4)花生油溶剂对照组;(5)自然对照组。实验78周,全肿瘤发生率分别为25/48,16/48, 36/44,11/48,20/44。肝肿瘤分别为3/48,6/48,27/48,2/48,1/44。150只大鼠分为五组,高、低剂量组和联苯胺阳性对照组分别为1000,400,30毫克/公斤。实验104周。全肿瘤分别为2/28,7/28,26/29,3/27,6/27。肝肿瘤为0,0,11/26,0,1/27。
Male Kunming mice and Wistar rats were used. 250 mice were divided into five groups: (1) 2-AAQ high dose group (2000 mg / kg); (2) 2-AAQ low dose group (400 mg / kg); (3) benzidine positive control group 150 mg / kg); (4) peanut oil solvent control group; (5) natural control group. After 78 weeks of experiment, the incidence of total tumor was 25/48, 16/48, 36/44, 11/48 and 20/44, respectively. The liver tumors were divided into three groups: 3/48, 6/48, 27/48, 2/48 and 1: 44.150, respectively. The rats in the high and low dose groups and the benzidine positive control group were 1000, 400, 30 mg / kg. Experiment 104 weeks. Total tumors were 2/28, 7/28, 26/29, 3/27, 6/27, respectively. Liver tumors were 0,0,11 / 26,0,1 / 27.