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目的观察神经系统常见疾病患儿血清丙二醛(MDA)的含量变化,旨在探讨自由基与神经系统疾病的关系,为临床防治神经系统疾病提供理论依据。方法采用Britton-Robinson硫代巴比妥酸缓冲液控制体系显色法检测,37例神经系统疾病患儿血清MDA,并与15例上呼吸道感染患儿和50例健康儿童对照。结果神经系统疾病组患儿血清MDA含量高于正常组(P<0.05),上呼吸道感染组与正常组比较无显著性差异(P>0.05)。结论神经系统疾病患儿血清MDA含量高于健康儿童,表明患儿体内脂质过氧化亢进及抗氧化能力降低,提示自由基参与疾病病理过程,这一点为临床应用自由基清除剂预防和治疗神经系统疾病提供了理论依据。
Objective To observe the changes of serum malondialdehyde (MDA) in children with common nervous system diseases and to explore the relationship between free radicals and nervous system diseases and provide theoretical basis for clinical prevention and treatment of nervous system diseases. Methods The Britton-Robinson thiobarbituric acid buffer control system was used to detect the serum levels of MDA in 37 children with neurological diseases and compared with 15 children with upper respiratory tract infection and 50 healthy children. Results Serum MDA levels in children with neurological disease group were higher than those in normal group (P <0.05). There was no significant difference between the upper respiratory tract infection group and normal group (P> 0.05). Conclusion Serum MDA levels in children with neurological diseases are higher than those in healthy children, indicating that hyperlipidemia and anti-oxidative capacity are reduced in children, suggesting that free radicals may participate in the pathological process of the disease. This is the clinical application of free radical scavengers to prevent and treat nerves System diseases provide a theoretical basis.