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目的分析漳州市454例初治涂阳肺结核化疗不良反应的影响因素,探索应对方法。方法对漳州市2014年1~6月份发现的454例初治涂阳治疗满1年的病历进行分析,用logistic回归分析(逐步后退法),观察性别、年龄组、职业、户籍、地区和药品类型等因素与肝功能损害的关系。结果454例患者抗结核化疗不良反应发生率20.3%,其中肝功能损害发生率11.7%。肝功损害率较高的为男性、35~49岁者和沿海患者。结论防止和减少沿海地区中年男性患者肝功能损害发生率,是减少抗结核化疗不良反应的发生、提高患者依从性、控制初治涂阳肺结核疫情的有效措施。
Objective To analyze the influencing factors of adverse reactions of smear-positive pulmonary tuberculosis in 454 newly-treated patients in Zhangzhou City, and to explore the coping methods. Methods A total of 454 cases of newly diagnosed smear positive smear were collected from January to June 2014 in Zhangzhou City. The data were analyzed by logistic regression (step by step regression), sex, age group, occupation, household register, region and drug Type and other factors and the relationship between liver damage. Results The incidence of adverse reactions of antituberculosis chemotherapy in 454 patients was 20.3%, of which the incidence of hepatic dysfunction was 11.7%. Higher rates of liver damage for men, 35 to 49 years old and coastal patients. Conclusion Preventing and reducing the incidence of liver damage in middle-aged male patients in coastal areas is an effective measure to reduce the incidence of adverse reactions to anti-TB chemotherapy, improve patient compliance and control the outbreak of smear-positive pulmonary tuberculosis.