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本文介绍了胎肝细胞悬液静脉输注治疗慢性重症肝炎,通过3例临床观察,病人腹胀、恶心呕吐,食欲不振等主观症状及肝功能、凝血功能均有不同程度的改善,显示了一定的疗效.同时简述了胎旰细胞悬液的制备方法,其疗效机理可能是为受体肝脏提供了暂时而有效的代偿支持作用,胎旰细胞的裂解产物刺激受体肝细胞再生,它所释放的免疫调控因子阻止受体肝细脏细胞进一步坏死.文中对治疗中可能出现的免疫排斥和ABO血型等问题进行了一般讨论.
This article describes the fetal liver cell suspension intravenous infusion of chronic severe hepatitis, through 3 clinical observations, patients with abdominal distension, nausea and vomiting, loss of appetite and other subjective symptoms and liver function, coagulation have varying degrees of improvement, showing a certain Curative effect.At the same time, the preparation method of fetal cell suspension was briefly introduced.The curative effect mechanism may provide a temporary and effective compensatory support for the recipient liver. The fetal cell lysate stimulated the regeneration of the recipient hepatocyte, Released immunomodulatory factors prevent further necrosis of the recipient liver somatic cells.We discuss the possible immunological rejection and ABO blood type in the treatment.