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本文目的在于通过体外及体内方法测定哮喘患者月—肾上腺素能受体数目及反应性,并与健康人做对照。正常人及病人注射肾上腺素前后在血压、心率、肺功能,血糖、Bmax各项间均有显著性差异;且病人及健康人血糖变化与Bmax变化呈线性明显相关(P<0.05)。病情发作严重、短期内应用月受体激动剂较多者,Bmax下降,Bmax与病程关系不大。应用Bmax或注射肾上腺素观察血糖变化,结合患者病情及用药情况,可以推测9—受体敏感性,从而指导临床恰当应用9—受体激动剂,并为今后如何恢复犀—受体功能研究打下基础。 支气管哮喘与喘息性支气管炎为常见病、多发病,是造成慢性呼吸衰竭的重要原因。由于归—肾上腺素能受体(下称“受体)激动剂广泛应用于治疗哮喘,因此哮喘患者月受体功能也受到重视。早在1968年Szentivanyi就提出哮喘与”受体功能阻滞有关。近年来,国内外学者对实验性哮喘动物肺组织“受体进行了大量研究,深化了人们对哮喘的认识。国外学者认为,外周血液淋巴细胞月受体变化与肺组织中的变化一致,国内吕氏在建立完整淋巴细胞9受体测定方法的基础上,动态观察了实验性过敏哮喘豚鼠血液淋巴细胞中9受体最大结合容量(下称Bmax)和CAMP含量,注意到哮喘后期血液夕受体的变化与肺组织的相一致。外周血液淋巴细胞是很容易获得的
The aim of this article is to determine the number and reactivity of the adrenoceptors in asthma by in vitro and in vivo methods and to compare them with healthy controls. Blood pressure, heart rate, lung function, blood glucose and Bmax were significantly different between normal and patients before and after injection of epinephrine. There was a linear correlation between blood glucose and Bmax in patients and healthy people (P <0.05). Severe seizures, short-term use of more receptor agonists, Bmax decreased, Bmax and the course of the disease is not. Bmax or injection of epinephrine observed changes in blood glucose, combined with the patient’s condition and medication, we can speculate 9-receptor sensitivity, which guide the clinical application of 9-receptor agonist, and for the future how to restore rhino-receptor function lay basis. Bronchial asthma and asthmatic bronchitis is a common disease, frequently-occurring disease, is an important cause of chronic respiratory failure. Because of the widespread use of the guanine-adrenergic receptor (hereinafter referred to as the ”receptor“) agonist for the treatment of asthma, the function of the monthly receptor of asthma patients has also been highlighted. As early as 1968 Szentivanyi proposed asthma and ”receptor resistance Hysteresis related. In recent years, scholars at home and abroad have done a lot of research on the experimental lung tissue of asthmatic animals, deepening people’s understanding of asthma.According to foreign scholars, the change of the monthly receptor of peripheral blood lymphocytes is consistent with that of the lung tissue, Based on the establishment of a complete lymphocyte 9 receptor assay in vivo, the maximal binding capacity of 9 receptors (hereinafter referred to as Bmax) and CAMP in the blood lymphocytes of experimental allergic asthmatic guinea pigs were dynamically observed. Receptor changes consistent with lung tissue. Peripheral blood lymphocytes are readily available