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目的通过比较接受常规体外受精技术(IVF)及卵胞浆单精子注射技术(ICSI)治疗后妊娠的病例,分析临床资料、妊娠及产科结局,从而评估其安全性。方法对中山大学附属第一医院1998年1月至1999年12月接受体外受精-胚胎移植治疗后妊娠的533例临床资料进行回顾性分析。结果ICSI组受精率明显高于IVF组,IVF和ICSI两组早期胚胎发育情况、产科结局、围生情况及出生后婴儿的健康情况差异无显著性意义。结论与常规IVF相比,ICSI并不增加胎儿畸形率及新生儿并发症,但仍需要长期的大量的随访以排除可能的危险性。
Objectives To assess the safety of clinical trials, pregnancy and obstetric outcomes by comparing cases of pregnancy treated with conventional IVF and ICSI. Methods The clinical data of 533 pregnant women receiving IVF-ET from January 1998 to December 1999 in the First Affiliated Hospital of Sun Yat-sen University were analyzed retrospectively. Results The fertilization rate of ICSI group was significantly higher than that of IVF group. There was no significant difference in IVF and ICSI early embryo development, obstetric outcome, perinatal condition, and postnatal infant health status. Conclusion ICSI does not increase fetal malformation rate and neonatal complications compared with conventional IVF, but a long period of follow-up is still needed to rule out the possible risk.