论文部分内容阅读
目的:研究动脉粥样硬化(AS)家兔血浆内皮素(ET)、左室舒张功能(LVDF)的变化及其之间的相关性。方法:32只4个月龄的雄性日本大耳白兔按喂养的不同时间(4周、12周)随机分为对照组和实验组,实验组家兔喂高脂饲料,对照组喂以普通饲料。分别于4周末、12周末检测血浆ET含量、超声测量左室射血分数(LVEF)、舒张早期峰值速度(Em)、舒张晚期峰值速度(Am)及Em/Am,并将ET和Em/Am作相关性分析。结果:12周末,实验组与对照组比较,ET含量显著增高(P<0.01),Em减低、Am增高、Em/Am<1,Em/Am较对照组显著降低(P<0.01),ET与Em/Am呈显著负相关(P<0.01)。结论:高脂饲料饲养家兔模型中,ET含量增加伴LVDF降低,ET和LVDF具有负相关性。
Objective: To study the changes of plasma endothelin (ET) and left ventricular diastolic function (LVDF) in rabbits with atherosclerosis (AS) and its correlation. Methods: Thirty-two male Japanese white rabbits, 4 months old, were randomly divided into control group and experimental group at different times of feeding (4 weeks and 12 weeks). In experimental group, rabbits were fed with high fat diet, feed. The levels of plasma ET, the left ventricular ejection fraction (LVEF), the early diastolic peak velocity (Em), the peak diastolic velocity (Am) and the ratio of Em / Am were measured at the end of 4th and 12th week respectively. ET and Em / Am Make correlation analysis. Results: At the end of the 12th week, the content of ET in the experimental group and the control group were significantly increased (P <0.01), Em decreased, Am increased, Em / Am <1 and Em / Am decreased significantly Em / Am was significantly negative correlation (P <0.01). CONCLUSION: In high fat diets fed with rabbits, the content of ET increased with the decrease of LVDF, and ET and LVDF had a negative correlation.