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目的:观察辛伐他汀对去卵巢大鼠血清细胞因子IL-6和IGF-I水平的影响。方法:选择健康雌性Wistar大鼠27只,3月龄,体重(200±30)g,随机分为A、B、C3组,每组9只。A组行开关术,其余两组行双侧卵巢切除术。术后1周A、B两组均灌服生理盐水1.5ml/只/d,C组给予辛伐他汀5mg/kg/d,共10周。双能X线骨密度仪测量股骨和胫骨骨密度(BMD);ELISA定量测定血清细胞因子IL-6、IGF-I水平。结果:B组血清IL-6水平明显高于A、C组(P<0.001)。C组血清IGF-I水平与B组比较差异无显著性(P>0.05);A组血清IGF-I水平明显高于B组(P<0.001)。股骨BMD和胫骨BMD与血清IL-6水平均呈显著负相关(P<0.001),而与血清IGF-I水平均呈显著正相关(P<0.05)。结论:他汀类药物能够下调IL-6的表达水平;但对IGF-I影响作用不大。
Objective: To observe the effects of simvastatin on the levels of serum cytokines IL-6 and IGF-I in ovariectomized rats. Methods: Twenty-seven healthy female Wistar rats were randomly divided into three groups (A, B and C3), 9 months old. A group of switch surgery, the other two groups of bilateral ovariectomy. One week after operation, both A and B groups were given normal saline 1.5ml / only / d, and C group was given simvastatin 5mg / kg / d for 10 weeks. The bone mineral density (BMD) of the femur and tibia was measured by dual energy X-ray absorptiometry. The levels of serum cytokines IL-6 and IGF-I were measured by ELISA. Results: The level of serum IL-6 in group B was significantly higher than that in group A and C (P <0.001). The level of serum IGF-I in group C was not significantly different from that in group B (P> 0.05). The level of serum IGF-I in group A was significantly higher than that in group B (P <0.001). Femoral BMD and tibia BMD were negatively correlated with serum IL-6 level (P <0.001), but positively correlated with serum IGF-I level (P <0.05). Conclusion: Statins can down-regulate the expression of IL-6, but have little effect on IGF-I.