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采用高效液相色谱-电化学检测器检测大鼠（180只）脑损伤后脑皮质及脑微血管中5－HT含量变化，并选用5-HT受体阻断剂赛庚啶治疗，观察其对脑损伤后脑皮质及脑微血管5－HT水平变化的影响。结果表明：脑损伤后5－HT水平显著升高，神经细胞和脑微血管内皮细胞病理变化与5－HT代谢改变有密切关系。赛庚啶可显著降低脑皮质及脑微血管中5－HT含量，并减轻脑继发性损害。
The contents of 5-HT in brain cortex and brain microvessel were detected by high performance liquid chromatography-electrochemical detector in rats (180 rats), and 5-HT receptor blocker, cyproheptadine Effects of 5-HT on cerebral cortex and cerebral microvascular after injury. The results showed that the level of 5-HT was significantly increased after brain injury, and the pathological changes of nerve cells and brain microvascular endothelial cells were closely related to the changes of 5-HT metabolism. Cyproheptadine can significantly reduce the 5-HT content in the cerebral cortex and brain microvessels, and reduce secondary brain damage.