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目的探讨氯吡格雷联合氟伐他汀治疗脑梗死的临床疗效。方法选取2014年1月—2016年1月任丘市人民医院神经内科收治的脑梗死患者72例,按照双盲法分为对照组与观察组,各36例。两组患者均给予常规治疗,对照组在常规治疗的基础上给予氯吡格雷治疗,观察组予以氯吡格雷联合氟伐他汀治疗。观察两组患者临床疗效、血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、C反应蛋白水平、神经功能缺损评分、生活质量评分、用药时间及不良反应发生情况。结果观察组总有效率高于对照组,差异有统计学意义(P<0.05);治疗前两组患者TC、TG、LDL-C、C反应蛋白水平比较,差异无统计学意义(P<0.05),治疗后两组患者TC、TG、LDL-C、C反应蛋白水平比较,差异有统计学意义(P<0.05);两组患者神经功能缺损评分、生活质量评分、用药时间比较,差异有统计学意义(P<0.05)。结论氯吡格雷联合氟伐他汀治疗脑梗死的临床疗效显著,可改善患者临床症状,且不良反应少。
Objective To investigate the clinical effect of clopidogrel combined with fluvastatin on cerebral infarction. Methods Seventy-two patients with cerebral infarction who were admitted to Renqiu People’s Hospital from January 2014 to January 2016 were divided into control group and observation group according to double-blind method, with 36 cases in each group. The patients in both groups were given routine treatment. The control group was given clopidogrel on the basis of routine treatment. The observation group was treated with clopidogrel combined with fluvastatin. The clinical efficacy, serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), C-reactive protein, neurological deficit score, quality of life score, Reaction occurred. Results The total effective rate in the observation group was higher than that in the control group (P <0.05). There was no significant difference in TC, TG, LDL-C and C-reactive protein between the two groups before treatment (P <0.05 ). There were significant differences in TC, TG, LDL-C and C-reactive protein levels between the two groups after treatment (P <0.05). There was significant difference between the two groups in neurological deficit score, quality of life score and medication duration Statistical significance (P <0.05). Conclusion Clopidogrel combined with fluvastatin is effective in treating cerebral infarction. It can improve the clinical symptoms of patients with less adverse reactions.