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目的探讨尾加压素Ⅱ、NT-proBNP在慢性心力衰竭不同心功能级别中的含量变化及其相关性。方法入选96例心力衰竭患者,其中心功能Ⅰ级22例;心功能Ⅱ级24例;心功能Ⅲ级26例;心功能IV级24例及20例对照组患者,测定血浆中尾加压素Ⅱ、NT-proBNP含量及心脏彩超查EF值、左室舒张末内径。结果尾加压素Ⅱ浓度在对照组、心衰组、心功能1级、心功能Ⅱ级、心功能Ⅲ级、心功能IV级分别为(5.05±0.80)ng/ml、(3.15±0.60)ng/ml、(4.65±0.82)ng/ml、(3.25±0.69)ng/ml、(2.35±0.49)ng/ml、(1.45±0.49)ng/ml;LgNT-proBNP浓度在对照组、心衰组、心功能1级、心功能Ⅱ级、心功能Ⅲ级、心功能IV级分别为(1.60±0.23)pg/ml、(2.82±0.15)pg/ml、(2.02±0.13)pg/ml、(2.85±0.28)pg/ml、(3.25±0.76)pg/ml、(4.25±0.47)pg/ml。结论在心力衰竭患者中,随心功能级别的增高,尾加压素Ⅱ逐渐减低,NT-proBNP逐渐增高,两则具有显著负相关性,可以通过联合应用来诊断心力衰竭。
Objective To investigate the changes of urotensin Ⅱ and NT-proBNP levels in patients with chronic heart failure and their correlations. Methods Ninety-six patients with heart failure were enrolled in this study. Twenty-two of them were grade Ⅰ in heart function, 24 in heart function class Ⅱ, 26 in heart function class Ⅲ, 24 in cardiac function class Ⅳ and 20 in control group. Urinary levels of urotensin Ⅱ , NT-proBNP content and echocardiography EF value, left ventricular end-diastolic diameter. Results Urotensin Ⅱ concentration in the control group, heart failure group, heart function 1, heart function Ⅱ, heart function Ⅲ, heart function Ⅳ grade were (5.05 ± 0.80) ng / ml, (3.15 ± 0.60) (4.65 ± 0.82) ng / ml, (3.25 ± 0.69) ng / ml, (2.35 ± 0.49) ng / ml, (1.45 ± 0.49) ng / ml respectively.LgNT-proBNP concentration in the control group, (1.60 ± 0.23) pg / ml, (2.82 ± 0.15) pg / ml, (2.02 ± 0.13) pg / ml, (2.85 ± 0.28) pg / ml, (3.25 ± 0.76) pg / ml, (4.25 ± 0.47) pg / ml. Conclusions In patients with heart failure, urotensin II is gradually decreased and NT-proBNP is gradually increased with the increase of cardiac function level. The two have significant negative correlation and can be used to diagnose heart failure.